This Report is jointly prepared by the International Centre for Higher Education Innovation under the auspices of UNESCO (UNESCO-ICHEI) and the Institute of Education (IOE) of Tsinghua University, focusing on the digital transformation of teaching and learning. This report analyses the background, current situation and framework, and elaborates on the transformation content, characteristics, strategies and directions from six aspects, including institutions and majors. It aims to respond to the numerous challenges faced in the process of promoting the digital transformation of higher education, and provides relevant parties with ideas and methods for dealing with the digital transformation of teaching.